After MAP insertion, an immediate vascular response is set in motion. The measurable increase in vascular expression is a function of a multitude of parameters such as needle depth, needle spacing, subject predisposition, repeat applications etc…
Understanding these relationships is paramount, as they have a strong impact on the pharmacokinetic availability of active substances over time. Dynamic OCT is useful to analyze the evolving interdependencies, and we present here imaging and measurements of vascular changes due to MAP insertion: