Atopic Dermatitis

VivoSight can image and measure skin changes resulting from Atopic Dermatitis

VivoSight Dx capabilities include analyzing microscopic and functional skin changes, such as:

  • Epidermal remodeling and thickness measurement
  • Inflammation and hidden abnormalities, as measured by alterations in vascular morphology, density and blood flow
  • Optical attenuation (as a proxy for collagen density)
  • Skin surface roughness
Location determination and morphology assessment of the superficial vascular plexus aid in the management of AD

Epidermal Alterations

Structural OCT images from subjects with different AD presentations [1]:

OCT image of healthy individual with no history of AD
OCT image captured from an uninvolved site on an eczema patient, showing slightly extended rete-pegs and an undulating DEJ
OCT image captured from an involved site on a different eczema patient, showing what appears to be inflammatory acanthosis (Long thin epidermal papillae/rete-pegs)

Vascular Alterations 

  • A selection of 2D angiographic OCT images of the popliteal fossa shows significant differences in detected superficial vascular plexus depth (SPD) for different EASI scores, and further showing morphological differences [1] 
  • SPD has potential as a non-invasive biomarker of severity of AD and sub-clinical inflammation
Healthy Subject
AD patient, unaffected area. Local EASI = 0
Patient with mild AD. 0 < Local EASI < 5
Patient with severe AD. Local EASI < 5
References:

1. Byers RA, Maiti R, Danby SG, Pang EJ, Mitchell B, Carre MJ, Lewis R, Cork MJ, Matcher SJ. Sub-clinical assessment of atopic dermatitis severity using angiographic optical coherence tomography. Biomedical Optics Express (BOE), Vol. 9, No. 4, 1 Apr 2018.

2. Manfredini M, Liberati S, Ciardo S, et al. Microscopic and functional changes observed with dynamic optical coherence tomography for severe refractory atopic dermatitis treated with dupilumab. Skin Res Technol. 2020;00:1– 9. https://doi.org/10.1111/srt.12868

3. Conti A, Ciardo S, Mandel VD, Bigi L, Pellacani G. Speckled variance optical coherence tomography for the assessment of nail involvement in acrodermatitis continua of Hallopeau: A case study. Journal of International Medical Research 2016, Vol. 44(1S) 119–123